In those days ,books could only be produ...

In those days ,books could only be produced one at a time _____________.

A. in hand B. with hand　

C. by hand D. by hands

C 【解析】试题分析：in hand 在手头，在控制中；with hand用手；by hand 用手，手工的；by hands无此说法。句意：在哪个时代，书籍只能手工一本一本地写。With一般表示用某种工具，by表示用某种方式，结合语境可知本句中强调书籍的生产方式，故选C。考点：考查介词短语。

考点分析：

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