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His sister left home in 1998, and since...

 His sister left home in 1998, and        since.

A. had not been heard of                B. has not been heard of

C. had not heard of                                         D. has not heard of

 

 B。 【解析】句意为:他的妹妹在1998年离开家,自从那时就没有音讯了。用现在完成时的否定结构。
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