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One of the most important questions the...

 One of the most important questions they had to consider was      of public health

A. what                                 B. this

C. that                                 D. which

 

 C。 【解析】句意为:他们必须考虑其中最重要的问题是公共卫生。考查that作代词,that 作代词,往往用于特指,相当于“that+名词”,它也只能代替事情不能代替人。
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