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-How amazing it is that astronauts are ...

 -How amazing it is that astronauts are exploring outer space!  

-It’s a challenge, I guess,            man against nature.  

A. of         B. for             C. by           D. about  

 

 A 应答句中的I guess是插入语,因此所填介词与challenge连用,表所属,用of,选A。
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